Studies on Proteinases fromGliocladium roseum

Nematicidal epipolysulfanyldioxopiperazines from Gliocladium roseum.

Five new verticillin-type epipolysulfanyldioxopiperazines, gliocladine A (1), B (2), C (3), D (4), and E (5), were isolated from wheat solid-substrate fermentation of Gliocladium roseum 1A, along with four known compounds, verticillin A (6), 11'-deoxyverticillin A (7), Sch52900 (8), and Sch52901 (9). Their structures were elucidated by extensive 1D and 2D NMR studies, MS, and chemical transform...

Improved CMCase production by Spicellum roseum

Insulin Secretagogue Fraction of Argyrolobium Roseum

Argyrolobium roseum Cambers Jaub & Spauch; Papilionaceae, is a sexually reproducing, rare, annual herb that grows in tropical and sub-temperate tracts of the north-western Himalayan region of the Indian subcontinent; it has neither been documented for treating diabetes mellitus nor any other biological activity is attributed to this herb. Its ethanolic extract (KA-030) exhibited antihyperglycem...

A confederacy of proteinases.

The demolition of large buildings can be accomplished by a single explosive agent destroying a single class of structural components, namely weightbearing beams. Although the breakdown of tissues in disease has often been conceived to occur in an analogous manner, with a single proteinase degrading a single structural ECM protein, it has become clear that effective tissue destruction requires s...

Engineered resistance against proteinases.

Exogenous proteinase inhibitors are valuable and economically interesting protective biotechnological tools. We examined whether small proteinase inhibitors when fused to a selected target protein can protect the target from proteolytic degradation without simultaneously affecting the function and activity of the target domain. Two proteinase inhibitors were studied: a Kazal-type silk proteinas...